Detalhe da pesquisa
1.
Translational Development Strategies for TAK-063, a Phosphodiesterase 10A Inhibitor.
Int J Neuropsychopharmacol
; 23(8): 524-532, 2020 11 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32598478
2.
Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late-onset sepsis or necrotizing enterocolitis: a pilot study incorporating clinical outcomes.
Br J Clin Pharmacol
; 85(1): 147-159, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30281170
3.
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle.
Trop Anim Health Prod
; 51(2): 435-441, 2019 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30219998
4.
Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal in N-Methyl-d-Aspartate Receptor Antagonist-Induced Rat Models of Schizophrenia.
J Pharmacol Exp Ther
; 365(1): 179-188, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29440309
5.
A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys.
Mov Disord
; 33(5): 805-814, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29508924
6.
Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis.
Pulm Pharmacol Ther
; 52: 32-40, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30201409
7.
Development of autotaxin inhibitors: A series of zinc binding triazoles.
Bioorg Med Chem Lett
; 28(13): 2279-2284, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29798825
8.
Radioiodination and bioevaluation of rolipram as a tracer for brain imaging: In silico study, molecular modeling and gamma scintigraphy.
J Labelled Comp Radiopharm
; 61(6): 501-508, 2018 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29430688
9.
Influence of Polymers on the Physical and Chemical Stability of Spray-dried Amorphous Solid Dispersion: Dipyridamole Degradation Induced by Enteric Polymers.
AAPS PharmSciTech
; 19(6): 2620-2628, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29916195
10.
Pharmacokinetic profiles of 5 mg/kg ibudilast, a phosphodiesterase inhibitor, orally administered to dogs in fasted and non-fasted states. A preliminary study.
Pol J Vet Sci
; 21(2): 281-285, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30450866
11.
Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain.
Eur J Nucl Med Mol Imaging
; 44(2): 308-320, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27817159
12.
Enhanced anticancer efficacy of histone deacetyl inhibitor, suberoylanilide hydroxamic acid, in combination with a phosphodiesterase inhibitor, pentoxifylline, in human cancer cell lines and in-vivo tumor xenografts.
Anticancer Drugs
; 28(9): 1002-1017, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28727579
13.
The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.
Bioorg Med Chem Lett
; 27(23): 5167-5171, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29113762
14.
A phase I, randomized, proof-of-clinical-mechanism study assessing the pharmacokinetics and pharmacodynamics of the oral PDE9A inhibitor BI 409306 in healthy male volunteers.
Hum Psychopharmacol
; 32(1)2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28120486
15.
First-in-human study assessing safety, tolerability and pharmacokinetics of BI 409306, a selective phosphodiesterase 9A inhibitor, in healthy males.
Br J Clin Pharmacol
; 82(5): 1315-1324, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27378314
16.
Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors.
Bioorg Med Chem Lett
; 26(17): 4216-22, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27491708
17.
Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor.
Mol Pharmacol
; 88(5): 836-45, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26316540
18.
AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer.
J Pharmacol Exp Ther
; 352(2): 327-37, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25502803
19.
Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor.
Bioorg Med Chem
; 23(22): 7138-49, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26494583
20.
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors.
Bioorg Med Chem
; 23(13): 3426-35, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25936260